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PLOS NTDs: Ae. aegypti in Somaliland carry kdr mutations and show pyrethroid resistance after dengue upsurges

Research4/10/2026

Bản đồ điểm thu mẫu Ae. aegypti tại Somaliland, Hình 1 bài PLOS NTDs

A paper of 20 April 2026 in PLOS Neglected Tropical Diseases reports a molecular survey of Ae. aegypti in Hargeisa, Berbera and Burao (Somaliland) after dengue upsurges in 2022–2024. Voltage-gated sodium-channel mutations S989P, V1016G and F1534C were found; WHO bioassays in Hargeisa and Burao showed resistance to the pyrethroids tested.

Insects

Main points

  • Journal: PLoS Negl Trop Dis 20(4): e0014185. DOI 10.1371/journal.pntd.0014185. Received 13 June 2025; accepted 25 March 2026; published 20 April 2026.
  • Adults and larvae were collected; species confirmed by COI; vgsc screened; WHO tests with deltamethrin, permethrin, lambda-cyhalothrin and alpha-cypermethrin on females from Hargeisa and Burao (2024).
  • 24-hour mortality examples (Hargeisa): lambda-cyhalothrin 18%, deltamethrin 88%, alpha-cypermethrin 28%, permethrin 50% — all below the WHO susceptible threshold. The S989P/V1016G combination (more often reported in Asia) was present; mutation frequencies were higher in Burao.
  • Blood-meal analysis detected human and goat DNA in a subset of samples. The paper is Somaliland data, not a survey in Vietnam.

VPMA’s note

These are research results from Somaliland. Do not use these resistance figures to describe mosquito populations in Vietnam.

Source
PLOS Neglected Tropical Diseases
Published
20 April 2026
Section
Research · Insects
Journal
PLoS Negl Trop Dis 20(4): e0014185
DOI
10.1371/journal.pntd.0014185
Editorial note: This is a short summary and comment by VPMA, not a full copy. The original text and copyright belong to the source cited. Picture: Figure 1 of the PLOS NTDs paper (sampling-site map).

Source: PLOS Neglected Tropical Diseases (summarised in English by VPMA). Read the Vietnamese page.

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